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28,145 Structural mutations such as R175H, R249S, and G245S decrease the thermodynamic and kinetic stability of the DBD by disturbing its structure, resulting in a decrease in the protein melting temperature and the emergence of unfolded proteins at body temperature

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In a study, Pasteurellaceae, Alcaligenaceae, and Fusobacteria were more common in early prodromal PD stages vs

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In that case, you might have low vitamin B12 levels